The New England Journal of MedicineA Single Cycle of Rituximab for the Treatment of Severe Pemphigus Pascal Joly, M.D., Ph.D. BackgroundThe combination of multiple cycles of rituximab and intravenous immune globulins has been reported to be effective in patients with severe pemphigus. The aim of this study was to assess…

The New England Journal of Medicine  Treatment of Pemphigus Vulgaris with Rituximab and Intravenous Immune Globulin BackgroundPemphigus vulgaris is a potentially fatal autoimmune mucocutaneous blistering disease.Conventional therapy consists of high-dose corticosteroids, immunosuppressive agents, and intravenous immune globulin. MethodsWe studied patients with refractory pemphigus vulgaris involving 30% or more of their body-surface…

Narrowband UVB treatment of progressive macular hypomelanosisJournal of the American Academy of DermatologyMoon-Bum Kim, MD, PhD, Gun-Wook Kim, MD, Hyun-Ho Cho, MD, Hyun-Je Park, MD, Hoon-Soo Kim, MD, Su-Han Kim, MD, Byung-Soo Kim, MD, PhD, and Hyun-Chang Ko, MD Busan, Korea INTRODUCTIONProgressive macular hypomelanosis (PMH) is an acquired hypopigmentation disorder…

Successful treatment of pemphigus with biweekly 1-g infusions of rituximab: A retrospective study of 47 patients. Leshem YA, Hodak E, David M, Anhalt GJ, Mimouni D BACKGROUND: Rituximab is increasingly being appreciated as a remarkably effective treatment for pemphigus, mostly concomitantly with other immunosuppressive medications. The majority of studies have…

IntroductionTreatment modalities in pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are many and varied, although level 1 evidence supporting their use is limited. To date, only 2 systematic reviews exist to support the use of different treatment modalities to control this group of conditions. Overall, within the literature, the quality…

Archives of Dermatologic Research Immunoadsorption in Dermatology Enno Schmid IntroductionThe arrival of immunoadsorption (IA), also termed immunoapheresis, about 20 years ago [25] allowed the selective removal of Ig and immune complexes from patients’ circulation.IA has been successfully used in patients with systemic lupus erythematosus, myasthenia gravis, multiple sclerosis, dilated cardiomyopathy,…

Dermatology and Therapy (2012)Rituximab in the Treatment of Pemphigus Vulgaris A. Razzaque Ahmed Introduction: Rituximab is increasingly used in patients with pemphigus vulgaris (PV) who are nonresponders to conventional therapy. Methods: A PubMed search was conducted using the words pemphigus vulgaris and rituximab therapy from papers published between 2000 and…

British Association of Dermatologists’ guidelines for the management of bullous pemphigoid 2012 DefinitionBP is an autoimmune subepidermal blistering disease that typically affects the elderly but may rarely present in children and younger adults. Autoantibodies of IgG type (and less commonlyIgA, IgM and IgE) attack components of the adhesion complex of the…

REVIEW2011 by the American Academy of Dermatology, Incdoi:10.1016/j.jaad.2011.06.032 Definitions and outcome measures for bullous pemphigoid: Recommendations by an internationalpanel of experts Introduction-There have been only a handful of well-designed randomized controlled trials assessing the effectiveness of therapies for BP. -meta-analysis is a powerful tool that is used to pool data…

British Journal of Dermatology Treatment of severe pemphigus with a combination of immunoadsorption, rituximab, pulsed dexamethasone and azathioprine⁄mycophenolate mofetil; a pilot study of 23 patients M.Kasperkiewicz,MD Background It has been previously shown in a relatively small group of patients that a combination of immunoadsorption (IA) and rituximab with daily use…